Article
Telomeric recombination induced by dysfunctional telomeres.
Molecular biology of the cell - 15 Jan 2011
Brault Marie Eve, Autexier Chantal
Abstract excerpt
Telomere maintenance is essential for cellular immortality, and most cancer cells maintain their telomeres through the enzyme telomerase. Telomeres and telomerase represent promising anticancer targets. However, 15% of cancer cells maintain their telomeres through alternative recombination-based mechanisms, and previous analyses showed that recombination-based telomere maintenance can be activated after...
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