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Article

Evidence for allelic evolution of C/EBPalpha mutations in acute myeloid leukaemia.

British journal of haematology - 1 Nov 2003

Tiesmeier Jens, Czwalinna Andreas, Müller-Tidow Carsten, Krauter Jürgen, Serve Hubert, Heil Gerhard, Ganser Arnold, Verbeek Walter

Abstract excerpt

Transcription factor CCAAT/enhancer binding protein alpha (C/EBPalpha) is mutated in 6-10% of patients with acute myeloid leukaemia (AML). Recently, we reported the emergence of an N-terminal C/EBPalpha mutation after chemotherapy in a patient with secondary AML. The clone carrying the mutation became the dominant clone at relapse. This observation prompted us to compare the C/EBPalpha mutational status of 26 de...

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Source

Identifiers

PMID: 14616999
DOI: 10.1046/j.1365-2141.2003.04618.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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