A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes.

doi:10.1073/pnas.2335924100

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Article

A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes.

Proceedings of the National Academy of Sciences of the United States of America - 25 Nov 2003

Ley Timothy J, Minx Patrick J, Walter Matthew J, Ries Rhonda E, Sun Hui, McLellan Michael, DiPersio John F, Link Daniel C, Tomasson Michael H, Graubert Timothy A, McLeod Howard, Khoury Hanna, Watson Mark, Shannon William, Trinkaus Kathryn, Heath Sharon, Vardiman James W, Caligiuri Michael A, Bloomfield Clara D, Milbrandt Jeffrey D, Mardis Elaine R, Wilson Richard K

Abstract excerpt

In this pilot study, we used primary human acute myeloid leukemia (AML) cell genomes as templates for exonic PCR amplification, followed by high-throughput resequencing, analyzing approximately 7 million base pairs of DNA from 140 AML samples and 48 controls. We identified six previously described, and seven previously undescribed sequence changes that may be relevant for AML pathogenesis. Because the sequencing...

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Identifiers

PMID: 14614138
DOI: 10.1073/pnas.2335924100
PMCID: PMC283582

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