Article
From the molecular biology of prolactin and its receptor to the lessons learned from knockout mice models.
Genetic analysis : biomolecular engineering - 1 Nov 1999
Goffin V, Binart N, Clément-Lacroix P, Bouchard B, Bole-Feysot C, Edery M, Lucas B K, Touraine P, Pezet A, Maaskant R, Pichard C, Helloco C, Baran N, Favre H, Bernichtein S, Allamando A, Ormandy C, Kelly P A
Abstract excerpt
Prolactin (PRL), a polypeptide hormone secreted mainly by the pituitary and, to a lesser extent, by peripheral tissues, affects more physiological processes than all other pituitary hormones combined since it is involved in > 300 separate functions in vertebrates. Its main actions are related to lactation and reproduction. The initial step of PRL action is the binding to a specific membrane receptor, the PRLR,...
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