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Article

The role of prolactin and growth hormone in mammary gland development.

Molecular and cellular endocrinology - 29 Nov 2002

Kelly Paul A, Bachelot Anne, Kedzia Cécile, Hennighausen Lothar, Ormandy Christopher J, Kopchick John J, Binart Nadine

Abstract excerpt

Development and differentiation of the mammary gland occur primarily during pregnancy. Females homozygous (-/-) for the null mutation of the PRL receptor (PRLR) gene are sterile due to a complete failure of blastocysts to implant. In progesterone-treated mice pregnancy is rescued but the mammary gland is severely underdeveloped. Interestingly, females hemizygous for the PRLR (+/-) in their first lactation show an...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12431805
DOI: 10.1016/s0303-7207(02)00286-1

Genes

GHR
PRLR
PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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