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BRAF mutations in non-Hodgkin's lymphoma

1 Nov 2003

Abstract excerpt

Ras proteins control signalling pathways that are key regulators of several aspects of normal cell growth and malignant transformation. BRAF, which encodes an RAF family member in the downstream pathway of RAS, is somatically mutated in a number of human cancers. The activating mutation of BRAF is known to play a role in tumour development. As there have been no data on the BRAF mutation in non-Hodgkin's lymphoma...

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PMID: 14612909
DOI: 10.1038/sj.bjc.6601371

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