Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BRAF mutations in chronic lymphocytic leukemia.

Leukemia & lymphoma - 1 Jun 2013

Jebaraj Billy Michael Chelliah, Kienle Dirk, Bühler Andreas, Winkler Dirk, Döhner Hartmut, Stilgenbauer Stephan, Zenz Thorsten

Abstract excerpt

BRAF mutations have been shown to occur at a high frequency in melanoma and thyroid cancer, but also at lower frequencies in hematological malignancies. To assess the potential role of BRAF, we have sequenced exons 11 and 15 of BRAF in 138 cases with chronic lymphocytic leukemia (CLL) and 32 cases of B-cell prolymphocytic leukemia (B-PLL). We found an incidence of BRAF mutations of 2.8% in CLL (4/138), while no...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extracellular Signal-Regulated MAP Kinases
Share to Indoles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Mitogen-Activated Protein Kinases

Share to Niacinamide

Share to Phenylurea Compounds

Share to Sorafenib

Share to Sulfonamides

Source

Identifiers

PMID: 23088640
DOI: 10.3109/10428194.2012.742525

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

BRAF mutations in chronic lymphocytic leukemia.PMID 23088640Read ↗

Incidence of the BRAF V600E mutation in chronic lymphocytic leukaemia and prolymphocytic leukaemia.Semantic proximity Read ↗

Mutations in the RAS-BRAF-MAPK-ERK pathway define a specific subgroup of patients with adverse clinical features and provide new therapeutic options in chronic lymphocytic leukemiaSemantic proximity Read ↗

BRAF Alterations in Chronic Lymphocytic Leukemia: Genomic Landscape, Co-Mutation Patterns, and Clinical Relevance.Semantic proximity Read ↗

BRAF--a new player in hematological neoplasms.Semantic proximity Read ↗

BRAF mutation in hairy cell leukemiaSemantic proximity Read ↗

BRAF mutations in non-Hodgkin's lymphomaSemantic proximity Read ↗

Frequency Of TP53 Gene Mutation In Patients With Chronic Lymphocytic Leukaemia.Semantic proximity Read ↗

BRAF kinase domain mutations are present in a subset of chronic myelomonocytic leukemia with wild‐type RASSemantic proximity Read ↗

Sorafenib-Induced Apoptosis of Chronic Lymphocytic Leukemia Cells Is Associated with Downregulation of RAF and Myeloid Cell Leukemia Sequence 1 (Mcl-1)Semantic proximity Read ↗

BRAF inhibition in refractory hairy-cell leukemia.Semantic proximity Read ↗

Alternative<i>BRAF</i>mutations in<i>BRAF</i>V600E-negative hairy cell leukaemiasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.