Article
BRAF--a new player in hematological neoplasms.
Blood cells, molecules & diseases - 1 Jan 2000
Machnicki Marcin M, Stoklosa Tomasz
Abstract excerpt
BRAF oncogenic kinase has become a target for specific therapy in oncology. Genetic characterization of a predominant V600E mutation in melanoma, thyroid cancer, and other tumors became a focus for developing specific inhibitors, such as vemurafenib or dabrafenib. Our knowledge regarding the role of mutated BRAF in hematological malignancies has grown quickly as a result of new genetic techniques such as...
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