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Article

Unmasking the lung cancer epigenome.

Annual review of physiology - 1 Jan 2015

Belinsky Steven A

Abstract excerpt

The reprogramming of the epigenome through silencing of genes and microRNAs by cytosine DNA methylation and chromatin remodeling is critical for the initiation and progression of lung cancer through affecting all major cell regulatory pathways. Importantly, the fact that epigenetic reprogramming is reversible by pharmacological agents has opened new avenues for clinical intervention. This review focuses on the...

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Share to In Vitro Techniques
Share to Chromatin Assembly and Disassembly
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Neoplastic

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Share to Precancerous Conditions

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PMID: 25668024
DOI: 10.1146/annurev-physiol-021014-072018

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