Article
Norepinephrine transporter splice variants and their interaction with substrates and blockers.
European journal of pharmacology - 31 Oct 2003
Kitayama Shigeo, Dohi Toshihiro
Abstract excerpt
Norepinephrine transporter (NET), a member of the Na+/Cl--dependent neurotransmitter transporter family, displays species-specific isoforms produced by alternative RNA splicing. This occurs at 3'-flanking coding and noncoding regions, resulting in different carboxy-terminals. When these NET splice variants were expressed in cultured cell lines, the characteristics of substrate transport and the sensitivity to...
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