Article
Functional gene variation in the human norepinephrine transporter: association with attention deficit hyperactivity disorder.
Annals of the New York Academy of Sciences - 1 Jan 2008
Kim Chun-Hyung, Waldman Irwin D, Blakely Randy D, Kim Kwang-Soo
Abstract excerpt
The norepinephrine (NE) transporter (NET) is responsible for the re-uptake of NE into presynaptic nerve terminals, thus critically regulating noradrenergic signaling and homeostasis. Since NE signaling contributes to diverse brain functions, we hypothesize that promoter variation within the human NET gene (solute carrier family 6, member 2; SLC6A2) may impact risk for NE-related disorders, including depression,...
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