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Article

C-terminal region regulates the functional expression of human noradrenaline transporter splice variants.

The Biochemical journal - 1 Jan 2007

Sogawa Chiharu, Kumagai Kei, Sogawa Norio, Morita Katsuya, Dohi Toshihiro, Kitayama Shigeo

Abstract excerpt

The NET [noradrenaline (norepinephrine) transporter], an Na+/Cl--dependent neurotransmitter transporter, has several isoforms produced by alternative splicing in the C-terminal region, each differing in expression and function. We characterized the two major isoforms of human NET, hNET1, which has seven C-terminal amino acids encoded by exon 15, and hNET2, which has 18 amino acids encoded by exon 16, by...

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Identifiers

PMID: 16965261
DOI: 10.1042/BJ20060495
PMCID: PMC1698689

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