Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C-terminal region regulates the functional expression of human noradrenaline transporter splice variants.

The Biochemical journal - 1 Jan 2007

Sogawa Chiharu, Kumagai Kei, Sogawa Norio, Morita Katsuya, Dohi Toshihiro, Kitayama Shigeo

Abstract excerpt

The NET [noradrenaline (norepinephrine) transporter], an Na+/Cl--dependent neurotransmitter transporter, has several isoforms produced by alternative splicing in the C-terminal region, each differing in expression and function. We characterized the two major isoforms of human NET, hNET1, which ha...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Chlorocebus aethiops
Share to COS Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney

Share to Norepinephrine Plasma Membrane Transport Proteins

Share to Protein Isoforms

Share to Subcellular Fractions

Source

Open in PubMed Open full text

Identifiers

PMID: 16965261
DOI: 10.1042/BJ20060495
PMCID: PMC1698689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16965261-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C-terminal region regulates the functional expression of human noradrenaline transporter splice variants.PMID 16965261Read ↗

Determinants within the C-terminus of the human norepinephrine transporter dictate transporter trafficking, stability, and activity.Semantic proximity Read ↗

Investigation of the functional roles of the MELAL and GQXXRXG motifs of the human noradrenaline transporter using cysteine mutants.Semantic proximity Read ↗

A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters.Semantic proximity Read ↗

Cloning and Characterization of Human NTT5 and v7-3: Two Orphan Transporters of the Na+/Cl−-Dependent Neurotransmitter Transporter Gene FamilySemantic proximity Read ↗

Single nucleotide polymorphisms in the human norepinephrine transporter gene affect expression, trafficking, antidepressant interaction, and protein kinase C regulation.Semantic proximity Read ↗

The norepinephrine transporter in physiology and disease.Semantic proximity Read ↗

Norepinephrine transporter splice variants and their interaction with substrates and blockers.Semantic proximity Read ↗

Palmitoylation regulates norepinephrine transporter trafficking and expression and is potentially involved in the pathogenesis of postural orthostatic tachycardia syndromeSemantic proximity Read ↗

Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain.Semantic proximity Read ↗

Genetic or acquired deficits in the norepinephrine transporter: current understanding of clinical implicationsSemantic proximity Read ↗

Cloning and functional characterization of the human norepinephrine transporter gene promoterSemantic proximity Read ↗

Functional consequences of homo- but not hetero-oligomerization between transporters for the biogenic amine neurotransmitters.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.