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Zika Virus Replicons for Drug Discovery

15 Sept 2016

Abstract excerpt

The current epidemic of Zika virus (ZIKV) has underscored the urgency to establish experimental systems for studying viral replication and pathogenesis, and countermeasure development. Here we report two ZIKV replicon systems: a luciferase replicon that can differentiate between viral translation and RNA synthesis; and a stable luciferase replicon carrying cell line that can be used to screen and characterize...

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PMID: 27658737
DOI: 10.1016/j.ebiom.2016.09.013

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