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Article

High-throughput, luciferase-based reverse genetics systems for identifying inhibitors of Marburg and Ebola viruses

6 Apr 2014

Abstract excerpt

Marburg virus (MARV) and Ebola virus (EBOV), members of the family Filoviridae, represent a significant challenge to global public health. Currently, no licensed therapies exist to treat filovirus infections, which cause up to 90% mortality in human cases. To facilitate development of antivirals against these viruses, we established two distinct screening platforms based on MARV and EBOV reverse genetics systems...

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PMID: 24713118
DOI: 10.1016/j.antiviral.2014.03.018

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