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Article

Isolation and characterization of the gene encoding yeast debranching enzyme.

Cell - 3 May 1991

Chapman K B, Boeke J D

Abstract excerpt

Using a genetic screen aimed at identifying cellular factors involved in Ty1 transposition, we have identified a mutation in a host gene that reduces Ty1 transposition frequency. The mutant, dbr1, is also defective in the process of intron turnover. In dbr1 cells, excised introns derived from a variety of pre-mRNAs are remarkably stable and accumulate to levels exceeding that of the corresponding mRNA. The stable...

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Source

Identifiers

PMID: 1850323
DOI: 10.1016/0092-8674(91)90466-c

Genes

DBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Isolation and characterization of the gene encoding yeast debranching enzyme.PMID 1850323Read ↗

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Genome-wide identification of spliced introns using a tiling microarray.Semantic proximity Read ↗

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Severe growth defect in a Schizosaccharomyces pombe mutant defective in intron lariat degradation.Semantic proximity Read ↗

Healing for destruction: tRNA intron degradation in yeast is a two-step cytoplasmic process catalyzed by tRNA ligase Rlg1 and 5'-to-3' exonuclease Xrn1.Semantic proximity Read ↗

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