Article
HBV resistant to lamivudine: experimental and clinical studies.
Hepatobiliary & pancreatic diseases international : HBPD INT - 1 Nov 2002
Zhou Dong-Yao, Cao Yong-Jian, Lin Lian-Ying, Wang Hong, Huang Jian-Sheng
Abstract excerpt
OBJECTIVE: To identify the impact of lamivudine on HBV e antigen (HBeAg) seroconversion and HBV DNA level, and the appearance of Tyr-Met-Asn-Asp (YMDD) resistants. METHODS: Forty-seven hepatitis B patients were treated with oral lamivudine. ALT level and HBeAg were detected in the treatment on the zero, 3rd, 6th and 9th month respectively. The levels of HBV DNA and YMDD resistants were analyzed with PCR...
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