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Article

PTHrP rescues ATDC5 cells from apoptosis induced by FGF receptor 3 mutation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2003

Yamanaka Yoshitaka, Tanaka Hiroyuki, Koike Mio, Nishimura Riko, Seino Yoshiki

Abstract excerpt

UNLABELLED: An activation mutation in the FGFR3 gene causes ACH. The effects of the FGFR3 mutants on apoptosis were analyzed in a chondrogenic cell line. ACH chondrocytes exhibited marked apoptotic with downregulation of PTHrP expression. Rescue of these cells by PTHrP replacement implies a potential therapy for this disorder. INTRODUCTION: Achondroplasia (ACH), the most common form of short-limb dwarfism, and...

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Source

Identifiers

PMID: 12929929
DOI: 10.1359/jbmr.2003.18.8.1395

Genes

FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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PTHrP rescues ATDC5 cells from apoptosis induced by FGF receptor 3 mutation.PMID 12929929Read ↗

Molecular basis for the treatment of achondroplasia.Semantic proximity Read ↗

Insulin-like growth factor-1 rescues the mutated FGF receptor 3 (G380R) expressing ATDC5 cells from apoptosis through phosphatidylinositol 3-kinase and MAPK.Semantic proximity Read ↗

Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia.Semantic proximity Read ↗

Increased p21 expression in chondrocytes of achondroplasic children independently from the presence of the G380R FGFR3 mutation.Semantic proximity Read ↗

Overexpression of FGFR3, Stat1, Stat5 and p21Cip1 correlates with phenotypic severity and defective chondrocyte differentiation in FGFR3-related chondrodysplasias.Semantic proximity Read ↗

Delayed bone age due to a dual effect of FGFR3 mutation in Achondroplasia.Semantic proximity Read ↗

Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice.Semantic proximity Read ↗

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A Ser365->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasiaSemantic proximity Read ↗

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