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Article

Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development.

Molecular and cellular biology - 1 Aug 2004

Ueda Takeshi, Watanabe-Fukunaga Rie, Fukuyama Hidehiro, Nagata Shigekazu, Fukunaga Rikiro

Abstract excerpt

Mnk1 and Mnk2 are protein kinases that are directly phosphorylated and activated by extracellular signal-regulated kinase (ERK) or p38 mitogen-activated protein (MAP) kinases and implicated in the regulation of protein synthesis through their phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) at Ser209. To investigate their physiological functions, we generated mice lacking the Mnk1 or Mnk2...

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Identifiers

PMID: 15254222
DOI: 10.1128/MCB.24.15.6539-6549.2004
PMCID: PMC444855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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