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Article

HOXA9 has the hallmarks of a biological switch with implications in blood cancers.

Nature communications - 3 Oct 2022

Talarmain Laure, Clarke Matthew A, Shorthouse David, Cabrera-Cosme Lilia, Kent David G, Fisher Jasmin, Hall Benjamin A

Abstract excerpt

Blood malignancies arise from the dysregulation of haematopoiesis. The type of blood cell and the specific order of oncogenic events initiating abnormal growth ultimately determine the cancer subtype and subsequent clinical outcome. HOXA9 plays an important role in acute myeloid leukaemia (AML) prognosis by promoting blood cell expansion and altering differentiation; however, the function of HOXA9 in other blood...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36192425
DOI: 10.1038/s41467-022-33189-w
PMCID: PMC9530117

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HOXA9 has the hallmarks of a biological switch with implications in blood cancers.PMID 36192425Read ↗

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Higher expression levels of the HOXA9 gene, closely associated with MLL-PTD and EZH2 mutations, predict inferior outcome in acute myeloid leukemiaSemantic proximity Read ↗

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