Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Effect of HSP90 function inhibited on the telomerase and P53 mutant in breast cancer cells].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition - 1 Mar 2008

Li Xia, Deng Hua-Yu

Abstract excerpt

OBJECTIVE: To investigate the effect of heat shock protein 90 (Hsp90) function inhibited on the telomerase activity and P53 expression in human breast cancer cells, in which a specific inhibitor geldanamycin (GA) was used to inhibit Hsp90 function. METHODS: Human breast cancer cell line MDA-MB-435s was used for the study. Proliferation of MDA-MB-435s cells was measured with MTT assay. Cell cycle was analyzed by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzoquinones
Share to Cell Cycle
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flow Cytometry

Share to HSP90 Heat-Shock Proteins

Share to Lactams, Macrocyclic

Share to Mutant Proteins

Share to Telomerase

Source

Identifiers

PMID: 18630678

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Effect of HSP90 function inhibited on the telomerase and P53 mutant in breast cancer cells].PMID 18630678Read ↗

[Impact of HSP90 Inhibition on Viability and Cell Cycle in Relation to p53 Status].Semantic proximity Read ↗

Combination of AURKA inhibitor and HSP90 inhibitor to treat breast cancer with AURKA overexpression and TP53 mutations.Semantic proximity Read ↗

Heat shock protein 90Semantic proximity Read ↗

Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cellsSemantic proximity Read ↗

Geldanamycin and its derivatives as Hsp90 inhibitors.Semantic proximity Read ↗

Geldanamycin, a heat shock protein 90-binding agent, disrupts Stat5 activation in IL-2-stimulated cells.Semantic proximity Read ↗

[The effect of antisense hsp90 beta on the malignant phenotype and sensitivity of HeLa cells to chemotherapeutic drugs].Semantic proximity Read ↗

The heat shock protein 90-binding geldanamycin inhibits cancer cell proliferation, down-regulates oncoproteins, and inhibits epidermal growth factor-induced invasion in thyroid cancer cell lines.Semantic proximity Read ↗

High expression of HSP90 is associated with poor prognosis in patients with colorectal cancerSemantic proximity Read ↗

Using Natural Product Inhibitors to Validate Hsp90 as a Molecular Target in CancerSemantic proximity Read ↗

Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells.Semantic proximity Read ↗

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.