Bidirectional replication from an internal ori site of the linear N15 plasmid prophage.

doi:10.1093/nar/gkg856

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Bidirectional replication from an internal ori site of the linear N15 plasmid prophage.

Nucleic acids research - 15 Nov 2003

Ravin Nikolai V, Kuprianov Victor V, Gilcrease Eddie B, Casjens Sherwood R

Abstract excerpt

The prophage of coliphage N15 is not integrated into the chromosome but exists as a linear plasmid molecule with covalently closed hairpin ends (telomeres). Upon infection the injected phage DNA circularizes via its cohesive ends. Then, a phage-encoded enzyme, protelomerase, cuts the circle and forms the hairpin telomeres. N15 protelomerase acts as a telomere-resolving enzyme during prophage DNA replication. We...

Topics

Bacteriophages
DNA Helicases
DNA, Viral
DNA-Binding Proteins
Enzyme Precursors
Microscopy, Electron
Mutagenesis, Site-Directed
Mutation
Plasmids
Prophages
Proteins
Replication Origin
Telomerase
Trans-Activators
Viral Proteins
Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 14602914
DOI: 10.1093/nar/gkg856
PMCID: PMC275552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics