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Article

Modeling human mutations to understand TRIO GEF function during development.

Trends in neurosciences - 1 Jun 2023

Fingleton Erin, Roche Katherine W

Abstract excerpt

In a recent study, Bonnet and colleagues leveraged in silico structure prediction and human genetic data to understand the molecular regulation of the Rac1-activating guanie nucleotide exchange factor (Rac1-GEF) domain of Trio. Their work sheds new light on the role of Trio during axon guidance and explores the mechanism by which Trio GEF function is regulated in health and dysregulated in disease.

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Identifiers

PMID: 36959051
DOI: 10.1016/j.tins.2023.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Modeling human mutations to understand TRIO GEF function during development.PMID 36959051Read ↗

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