Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sugar recognition by human galactokinase.

BMC biochemistry - 4 Nov 2003

Timson David J, Reece Richard J

Abstract excerpt

BACKGROUND: Galactokinase catalyses the first committed step of galactose catabolism in which the sugar is phosphorylated at the expense of MgATP. Recent structural studies suggest that the enzyme makes several contacts with galactose--five side chain and two main chain hydrogen bonds. Furthermore, it has been suggested that inhibition of galactokinase may help sufferers of the genetic disease classical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Aspartic Acid
Share to Carbohydrate Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carbohydrates

Share to Galactokinase

Share to Glutamic Acid

Share to Phosphotransferases (Alcohol Group Acceptor)

Share to Solubility

Source

Open in PubMed Open full text

Identifiers

PMID: 14596685
DOI: 10.1186/1471-2091-4-16
PMCID: PMC280648

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sugar recognition by human galactokinase.PMID 14596685Read ↗

Functional studies of rat galactokinase.Semantic proximity Read ↗

Misfolding of galactose 1-phosphate uridylyltransferase can result in type I galactosemia.Semantic proximity Read ↗

Glucokinase: structural analysis of a protein involved in susceptibility to diabetes.Semantic proximity Read ↗

The structural and molecular biology of type IV galactosemia.Semantic proximity Read ↗

Substrate specificity and mechanism from the structure of Pyrococcus furiosus galactokinase.Semantic proximity Read ↗

Structural and molecular biology of type I galactosemia: disease-associated mutations.Semantic proximity Read ↗

Correlation assessment among clinical phenotypes, expression analysis and molecular modeling of 14 novel variations in the human galactose-1-phosphate uridylyltransferase gene.Semantic proximity Read ↗

Determinants of function and substrate specificity in human UDP-galactose 4'-epimerase.Semantic proximity Read ↗

Contribution of amino acid side chains to sugar binding specificity in a galactokinase, Gal1p, and a transcriptional inducer, Gal3p.Semantic proximity Read ↗

Structural model of human glucokinase in complex with glucose and ATP: implications for the mutants that cause hypo- and hyperglycemia.Semantic proximity Read ↗

Novel mutation in hexokinase 2 confers resistance to 2-deoxyglucose by altering protein dynamics.Semantic proximity Read ↗

Catalytic mechanism of human alpha-galactosidase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.