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Article

Determinants of function and substrate specificity in human UDP-galactose 4'-epimerase.

The Journal of biological chemistry - 30 Jul 2004

Schulz Jenny M, Watson Alice L, Sanders Rebecca, Ross Kerry L, Thoden James B, Holden Hazel M, Fridovich-Keil Judith L

Abstract excerpt

UDP-galactose 4'-epimerase (GALE) interconverts UDP-galactose and UDP-glucose in the final step of the Leloir pathway. Unlike the Escherichia coli enzyme, human GALE (hGALE) also efficiently interconverts a larger pair of substrates: UDP-N-acetylgalactosamine and UDP-N-acetylglucosamine. The basis of this differential substrate specificity has remained obscure. Recently, however, x-ray crystallographic data have...

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Source

Identifiers

PMID: 15175331
DOI: 10.1074/jbc.M405005200

Genes

GALE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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