Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Substrate specificity and mechanism from the structure of Pyrococcus furiosus galactokinase.

Journal of molecular biology - 19 Mar 2004

Hartley Andrew, Glynn Steven E, Barynin Vladimir, Baker Patrick J, Sedelnikova Svetlana E, Verhees Corné, de Geus Daniel, van der Oost John, Timson David J, Reece Richard J, Rice David W

Abstract excerpt

Galactokinase (GalK) catalyses the first step of the Leloir pathway of galactose metabolism, the ATP-dependent phosphorylation of galactose to galactose-1-phosphate. In man, defects in galactose metabolism can result in disorders with severe clinical consequences, and deficiencies in galactokinas...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Diphosphate
Share to Catalytic Domain
Share to Galactokinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Galactose

Share to Galactosemias

Share to Protein Folding

Share to Pyrococcus furiosus

Share to Static Electricity

Source

Identifiers

PMID: 15003454
DOI: 10.1016/j.jmb.2004.01.043

Genes

GAL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15003454-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Substrate specificity and mechanism from the structure of Pyrococcus furiosus galactokinase.PMID 15003454Read ↗

Contribution of amino acid side chains to sugar binding specificity in a galactokinase, Gal1p, and a transcriptional inducer, Gal3p.Semantic proximity Read ↗

Sites for interaction between Gal80p and Gal1p in Kluyveromyces lactis: structural model of galactokinase based on homology to the GHMP protein family.Semantic proximity Read ↗

Structure, Mutation, Functional Domain Roles and Medical Implications of Glycerol Kinase.Semantic proximity Read ↗

Structural and molecular biology of type I galactosemia: disease-associated mutations.Semantic proximity Read ↗

The structural and molecular biology of type IV galactosemia.Semantic proximity Read ↗

Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants.Semantic proximity Read ↗

Sugar recognition by human galactokinase.Semantic proximity Read ↗

The molecular biology of galactosemia.Semantic proximity Read ↗

Structure of protein O-mannose kinase reveals a unique active site architecture.Semantic proximity Read ↗

Toward a blueprint for UDP-glucose pyrophosphorylase structure/function properties: homology-modeling analyses.Semantic proximity Read ↗

Novel mutations in the GALK1 gene in patients with galactokinase deficiency.Semantic proximity Read ↗

The effect of ligand binding on the galactokinase activity of yeast Gal1p and its ability to activate transcription.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.