Article
Constitutive and agonist-dependent self-association of the cell surface human lutropin receptor.
The Journal of biological chemistry - 13 Feb 2004
Tao Ya-Xiong, Johnson Nathan B, Segaloff Deborah L
Abstract excerpt
The human lutropin receptor (hLHR) is a G protein-coupled receptor (GPCR) that plays an essential role in reproductive physiology. The present studies were undertaken to determine whether the hLHR self-associates. We show that high molecular weight complexes of the hLHR can be co-immunoprecipitated from 293 cells transfected with differentially tagged hLHRs. These complexes are detected only in extracts from...
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