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Article

Desensitization of Gs-coupled receptor signaling by constitutively active mutants of the human lutropin/choriogonadotropin receptor.

The Journal of clinical endocrinology and metabolism - 1 Mar 2003

Shinozaki Hiromitsu, Butnev Viktor, Tao Ya-Xiong, Ang Kok Long, Conti Marco, Segaloff Deborah L

Abstract excerpt

Activating mutations of the human lutropin/choriogonadotropin receptor (hLHR), a Gs-coupled receptor, have been identified in young boys with gonadotropin-independent precocious puberty (testotoxicosis). The properties of these mutants have typically been characterized in heterologous cells transfected with recombinant mutant receptor and compared with those expressing wild-type (wt) receptor. The affected...

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Source

Identifiers

PMID: 12629106
DOI: 10.1210/jc.2002-021051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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