Article
Scenarios for autoimmunization of T and B cells in myasthenia gravis.
Annals of the New York Academy of Sciences - 1 Sept 2003
Shiono H, Roxanis I, Zhang W, Sims G P, Meager A, Jacobson L W, Liu J-L, Matthews I, Wong Y-L, Bonifati M, Micklem K, Stott D I, Todd J A, Beeson D, Vincent A, Willcox N
Abstract excerpt
We have studied responses in thymoma patients to interferon-alpha and to the acetylcholine receptor (AChR) in early-onset myasthenia gravis (EOMG), seeking clues to autoimmunizing mechanisms. Our new evidence implicates a two-step process: (step 1) professional antigen-presenting cells and thymic epithelial cells prime AChR-specific T cells; then (step 2) thymic myoid cells subsequently provoke germinal center...
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