Article
Clonal heterogeneity of thymic B cells from early-onset myasthenia gravis patients with antibodies against the acetylcholine receptor.
Journal of autoimmunity - 1 Aug 2014
Vrolix Kathleen, Fraussen Judith, Losen Mario, Stevens Jo, Lazaridis Konstantinos, Molenaar Peter C, Somers Veerle, Bracho Maria Alma, Le Panse Rozen, Stinissen Piet, Berrih-Aknin Sonia, Maessen Jos G, Van Garsse Leen, Buurman Wim A, Tzartos Socrates J, De Baets Marc H, Martinez-Martinez Pilar
Abstract excerpt
Myasthenia gravis (MG) with antibodies against the acetylcholine receptor (AChR-MG) is considered as a prototypic autoimmune disease. The thymus is important in the pathophysiology of the disease since thymus hyperplasia is a characteristic of early-onset AChR-MG and patients often improve after thymectomy. We hypothesized that thymic B cell and antibody repertoires of AChR-MG patients differ intrinsically from...
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