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Article

Venous response to nitroglycerin is enhanced in young, healthy carriers of the 825T allele of the G protein beta3 subunit gene (GNB3).

Clinical pharmacology and therapeutics - 1 Nov 2003

Mitchell Anna, Bührmann Sandra, Seifert Anne, Nürnberger Jens, Wenzel René R, Siffert Winfried, Philipp Thomas, Schäfers Rafael F

Abstract excerpt

OBJECTIVE: The ultimate mode of action by which nitroglycerin elicits vasodilation remains elusive. Animal studies point to an involvement of pertussis toxin-sensitive G proteins. The 825T allele of the GNB3 C825T polymorphism in the gene encoding the G protein beta3 subunit is associated with enhanced signal transduction via pertussis toxin-sensitive pathways in vitro. We hypothesized that G proteins have a role...

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Source

Identifiers

PMID: 14586390
DOI: 10.1016/S0009-9236(03)00230-3

Genes

GNB3

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Venous response to nitroglycerin is enhanced in young, healthy carriers of the 825T allele of the G protein beta3 subunit gene (GNB3).PMID 14586390Read ↗

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