Article
Insulin-mediated venodilation is impaired in young, healthy carriers of the 825T allele of the G-protein beta3 subunit gene (GNB3).
Clinical pharmacology and therapeutics - 1 Jun 2005
Mitchell Anna, Pace Mutlu, Nürnberger Jens, Wenzel René R, Siffert Winfried, Philipp Thomas, Schäfers Rafael F
Abstract excerpt
OBJECTIVE: A C825T polymorphism has been identified for the gene encoding the G-protein beta 3 subunit ( GNB3 ). The 825T allele is associated with hypertension and obesity, which in turn are closely linked with resistance to the metabolic and vascular effects of insulin. We hypothesized that venodilation in response to insulin would be impaired in GNB3 825T-allele carriers. Because vasodilatory properties of...
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