Article
Effects of systemic endothelin A receptor antagonism in various vascular beds in men: in vivo interactions of the major blood pressure-regulating systems and associations with the GNB3 C825T polymorphism.
Clinical pharmacology and therapeutics - 1 Nov 2004
Mitchell Anna, Lückebergfeld Birte, Bührmann Sandra, Rushentsova Uljana, Nürnberger Jens, Siffert Winfried, Schäfers Rafael F, Philipp Thomas, Wenzel René R
Abstract excerpt
OBJECTIVE: We used the orally available endothelin A (ETA) receptor antagonist darusentan to characterize interactions between the major blood pressure-regulating systems in healthy men. Mediators of the endothelin system, the sympathetic nervous system, and the renin-angiotensin system act via G...
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