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The p38 Mitogen-Activated Protein Kinase Pathway Links the DNA Mismatch Repair System to the G 2 Checkpoint and to Resistance to Chemotherapeutic DNA-Methylating Agents

29 Oct 2003

Abstract excerpt

Although human cells exposed to DNA-methylating agents undergo mismatch repair (MMR)-dependent G(2) arrest, the basis for the linkage between MMR and the G(2) checkpoint is unclear. We noted that mitogen-activated protein kinase p38alpha was activated in MMR-proficient human glioma cells exposed to the chemotherapeutic methylating agent temozolomide (TMZ) but not in paired cells made MMR deficient by expression...

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PMID: 14585987
DOI: 10.1128/mcb.23.22.8306-8315.2003

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