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<i>In vitro</i> and <i>In vivo</i> Radiosensitization Induced by the DNA Methylating Agent Temozolomide

1 Feb 2008

Abstract excerpt

PURPOSE: Temozolomide, a DNA methylating agent, is currently undergoing clinical evaluation for cancer therapy. Because temozolomide has been shown to increase survival rates of patients with malignant gliomas when given combined with radiation, and there is conflicting preclinical data concerning the radiosensitizing effects of temozolomide, we further investigated the possible temozolomide-induced enhancement...

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PMID: 18245557
DOI: 10.1158/1078-0432.ccr-07-1856

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