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Mismatch-Repair Protein Expression in High-Grade Gliomas: A Large Retrospective Multicenter Study

14 Sept 2020

Abstract excerpt

BACKGROUND: DNA mismatch repair (MMR) is a system for repairing errors in DNA replication. Cancer cells with MMR deficiency can have immunohistochemical loss of MMR protein expression leading to a hypermutable phenotype that may correlate with anti-PD1 efficacy. Scant data exist about immunohistochemical loss of MMR protein expression in high-grade gliomas (HGG). MATERIALS AND METHODS: We performed a large...

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PMID: 32937743
DOI: 10.3390/ijms21186716

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