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Article

Dizygotic twinning is not associated with methylenetetrahydrofolate reductase haplotypes.

Human reproduction (Oxford, England) - 1 Nov 2003

Montgomery Grant W, Zhao Zhen Zhen, Morley Katherine I, Marsh Anna J, Boomsma Dorret I, Martin Nicholas G, Duffy David L

Abstract excerpt

BACKGROUND: Folate metabolism is critical to embryonic development, influencing neural tube defects (NTD) and recurrent early pregnancy loss. Polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR) have been associated with dizygotic (DZ) twinning through pregnancy loss. METHODS: The C677T and A1298C polymorphisms in MTHFR were genotyped in 258 Australasian families (1016 individuals) and 118 Dutch...

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Source

Identifiers

PMID: 14585902
DOI: 10.1093/humrep/deg441

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dizygotic twinning is not associated with methylenetetrahydrofolate reductase haplotypes.PMID 14585902Read ↗

The number of dichorionic twin pregnancies is reduced by the common MTHFR 677C-->T mutation.Semantic proximity Read ↗

Dizygotic twinning.Semantic proximity Read ↗

A deletion mutation in GDF9 in sisters with spontaneous DZ twins.Semantic proximity Read ↗

Utilizing twins as controls for non-twin case-materials in genome wide association studies.Semantic proximity Read ↗

S680N substitution of the follicle-stimulating hormone receptor is a common polymorphism not associated with spontaneous human twinning.Semantic proximity Read ↗

Variation in bone morphogenetic protein 15 is not associated with spontaneous human dizygotic twinning.Semantic proximity Read ↗

HLA and genomewide allele sharing in dizygotic twins.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphisms are not a risk factor for pre-eclampsia/eclampsia in Australian women.Semantic proximity Read ↗

667C>T and 1298A>C polymorphisms of MTHFR do not predict response to methotrexate in patients with gestational trophoblastic neoplasia.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T and A1298C variants do not affect ongoing pregnancy rates following IVF.Semantic proximity Read ↗

Polymorphisms within the vitamin B12 dependent methylmalonyl-coA mutase are not risk factors for neural tube defects.Semantic proximity Read ↗

Mechanisms of monozygotic (MZ) twinning: a possible role for the cell adhesion molecule, E-cadherin.Semantic proximity Read ↗

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