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Article

The number of dichorionic twin pregnancies is reduced by the common MTHFR 677C-->T mutation.

Human reproduction (Oxford, England) - 1 Dec 2000

Hasbargen U, Lohse P, Thaler C J

Abstract excerpt

In multiple pregnancies, demands for folic acid are considerably increased. The most common inborn error of folate metabolism is mild methylenetetrahydrofolate reductase (MTHFR) deficiency due to the synthesis of a thermolabile variant of the enzyme with impaired catalytic activity which leads to...

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Source

Identifiers

PMID: 11098041
DOI: 10.1093/humrep/15.12.2659

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11098041-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The number of dichorionic twin pregnancies is reduced by the common MTHFR 677C-->T mutation.PMID 11098041Read ↗

Mechanisms for differences in monozygous twins.Semantic proximity Read ↗

Dizygotic twinning is not associated with methylenetetrahydrofolate reductase haplotypes.Semantic proximity Read ↗

The "thermolabile" variant of methylenetetrahydrofolate reductase and neural tube defects: An evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother.Semantic proximity Read ↗

The Fertility Effects of the C677T Mutation in the Methylenetetrahydrofolate Reductase Gene: A Cross-Site Systematic Review and Meta-Analysis.Semantic proximity Read ↗

Low blood folates in NTD pregnancies are only partly explained by thermolabile 5,10-methylenetetrahydrofolate reductase: low folate status alone may be the critical factor.Semantic proximity Read ↗

Neonatal and fetal methylenetetrahydrofolate reductase genetic polymorphisms: an examination of C677T and A1298C mutations.Semantic proximity Read ↗

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Increased frequency of combined methylenetetrahydrofolate reductase C677T and A1298C mutated alleles in spontaneously aborted embryos.Semantic proximity Read ↗

A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group.Semantic proximity Read ↗

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The common 'thermolabile' variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia.Semantic proximity Read ↗

Decreased methylene tetrahydrofolate reductase activity due to the 677C-->T mutation in families with spina bifida offspring.Semantic proximity Read ↗

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