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Article

667C>T and 1298A>C polymorphisms of MTHFR do not predict response to methotrexate in patients with gestational trophoblastic neoplasia.

Gynecologic oncology - 1 Dec 2011

Lasecka Lidia, Dixon Peter H, Molokhia Mariam, Sharma Nima, Schleh Annabel, Wang Chiuhui Mary, Steel Jennifer H, Seckl Michael J, Savage Philip M, Fisher Rosemary A

Abstract excerpt

OBJECTIVE: Approximately one third of patients treated with methotrexate for gestational trophoblastic neoplasia (GTN) following a molar pregnancy are reported to develop resistance to methotrexate and need to change to different chemotherapeutic agents. Previous studies, in other clinical settings, have suggested that polymorphisms in key folate metabolising enzymes such as 5,10-methylenetetrahydrofolate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21920590
DOI: 10.1016/j.ygyno.2011.08.012

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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667C>T and 1298A>C polymorphisms of MTHFR do not predict response to methotrexate in patients with gestational trophoblastic neoplasia.PMID 21920590Read ↗

Presence of the methylenetetrahydrofolate reductase gene polymorphism MTHFR C677T in molar tissue but not maternal blood predicts failure of methotrexate treatment for low-risk gestational trophoblastic neoplasia.Semantic proximity Read ↗

The effect of parental 5,10-methylenetetrahydrofolate reductase 677C/T and 1298A/C gene polymorphisms on response to single-dose methotrexate in tubal ectopic pregnancy.Semantic proximity Read ↗

No evidence for association of MTHFR 677C>T and 1298A>C variants with placental DNA methylation.Semantic proximity Read ↗

The association of parental methylenetetrahydrofolate reductase polymorphisms (MTHFR 677C > T and 1298A > C) and fetal loss: a case-control study in South Australia.Semantic proximity Read ↗

Molecular distinction of consecutive molar pregnancies.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphism, folate, and susceptibility to preeclampsia.Semantic proximity Read ↗

MethotrexateSemantic proximity Read ↗

Neonatal and fetal methylenetetrahydrofolate reductase genetic polymorphisms: an examination of C677T and A1298C mutations.Semantic proximity Read ↗

ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing.Semantic proximity Read ↗

Analysis of the MTHFR 1298A-->C and 677C-->T polymorphisms as risk factors for neural tube defects.Semantic proximity Read ↗

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Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in the placenta of pregnancies complicated with preeclampsia.Semantic proximity Read ↗

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