Article
Utilizing twins as controls for non-twin case-materials in genome wide association studies.
PloS one - 1 Jan 2013
Ganna Andrea, Ortega-Alonso Alfredo, Havulinna Aki, Salomaa Veikko, Kaprio Jaakko, Pedersen Nancy L, Sullivan Patrick F, Ingelsson Erik, Hultman Christina M, Magnusson Patrik K E
Abstract excerpt
Twin registries around the globe have collected DNA samples from large numbers of monozygotic and dizygotic twins. The twin sample collections are frequently used as controls in disease-specific studies together with non-twins. This approach is unbiased under the hypothesis that twins and singletons are comparable in terms of allele frequencies; i.e. there are no genetic variants associated with being a twin per...
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