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Article

Age dependence of the influence of methylenetetrahydrofolate reductase genotype on plasma homocysteine level.

American journal of epidemiology - 1 Nov 2003

Spotila Loretta D, Jacques Paul F, Berger Peter B, Ballman Karla V, Ellison R Curtis, Rozen Rima

Abstract excerpt

An elevated plasma homocysteine level is a risk factor for cardiovascular disease and is often observed in other common disorders, including neural tube defects, pregnancy complications, and Alzheimer's disease. Plasma homocysteine level is affected by vitamin intake and by sequence variation in enzymes of homocysteine metabolism. One such enzyme, methylenetetrahydrofolate reductase (MTHFR), synthesizes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14585765
DOI: 10.1093/aje/kwg234

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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