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Article

Clinical relevance of the molecular mechanisms of resistance to anti-cancer drugs

25 Oct 1999

Abstract excerpt

Resistance to anti-cancer drugs (drug resistance) can be defined in the laboratory by the amount of anti-cancer drug that is required to produce a given level of cell death (drug response). Clinical drug resistance can be defined either as a lack of reduction of the size of a tumour following chemotherapy or as the occurrence of clinical relapse after an initial 'positive' response to anti-tumour treatment. Many...

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PMID: 14585120
DOI: 10.1017/s1462399499001099x

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