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Genomics and Cancer Drug Resistance

14 Mar 2012

Abstract excerpt

Cellular drug resistance is a major obstacle in cancer therapy. Mechanisms of resistance can be associated with altered expression of ATP-binding cassette (ABC) family of transporters on cell membrane transporters, the most common cause of multi-drug resistance (MDR), but can also include alterations of DNA repair pathways, resistance to apoptosis and target modifications. Anti-cancer treatments may be divided...

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PMID: 22122479
DOI: 10.2174/138920112799857549

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