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Article

BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2003

Rawadi Georges, Vayssière Béatrice, Dunn Fred, Baron Roland, Roman-Roman Sergio

Abstract excerpt

UNLABELLED: Wnt/beta-catenin signaling has recently been suggested to be involved in bone biology. The precise role of this cascade in osteoblast differentiation was examined. We show that a Wnt autocrine loop mediates the induction of alkaline phosphatase and mineralization by BMP-2 in pre-osteoblastic cells. INTRODUCTION: Loss of function of LRP5 leads to osteoporosis (OPPG syndrome), and a specific point...

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Source

Identifiers

PMID: 14584895
DOI: 10.1359/jbmr.2003.18.10.1842

Genes

LRP5
HBM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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