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A Lymphatic Mechanism of Rotavirus Extraintestinal Spread in the Neonatal Mouse

27 Oct 2003

Abstract excerpt

We used the neonatal mouse model of rotavirus infection and virus strains SA11-clone 4 (SA11-Cl4) and Rhesus rotavirus (RRV) to examine the mechanism of the extraintestinal spread of viruses following oral inoculation. The spread-competent viruses, RRV and reassortant R7, demonstrated a temporal progression from the intestine, to the terminal ileum, to the mesenteric lymph nodes (MLN), and to the peripheral...

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PMID: 14581572
DOI: 10.1128/jvi.77.22.12352-12356.2003

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