Article
Murine rotavirus genes encoding outer capsid proteins VP4 and VP7 are not major determinants of host range restriction and virulence.
Journal of virology - 1 May 1993
Broome R L, Vo P T, Ward R L, Clark H F, Greenberg H B
Abstract excerpt
Simian rotavirus (RRV) and murine rotavirus (EDIM-RW) differ dramatically in the oral inoculum required to cause diarrheal disease in neonatal mouse pups and in their ability to spread and cause disease in uninoculated littermates. A genetic approach was used to explore the molecular basis of the...
Topics
- Animals
- Animals, Suckling
- Antigens, Viral
- Capsid
- Capsid Proteins
- Diarrhea
- Feces
- Female
- Genes, Viral
- Genotype
- Intestines
- Mice
- Mice, Inbred Strains
- Phenotype
- Recombination, Genetic
- Rotavirus
- Species Specificity
- Viral Plaque Assay