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Article

Genetic mapping indicates that VP4 is the rotavirus cell attachment protein in vitro and in vivo

1 Jan 1996

Abstract excerpt

To identify the rotavirus protein which mediates attachment to cells in culture, viral reassortants between the simian rotavirus strain RRV and the murine strains EHP and EW or between the simian strain SA-11 and the human strain DS-1 were isolated. These parental strains differ in the requirement for sialic acid to bind and infect cells in culture. Infectivity and binding assays with the parental and reassortant...

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PMID: 8523562
DOI: 10.1128/jvi.70.1.487-493.1996

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Genetic mapping indicates that VP4 is the rotavirus cell attachment protein in vitro and in vivoPMID 8523562Read ↗

Characterization of Sialic Acid-Independent Simian Rotavirus Mutants in Viral Infection and Pathogenesis.Semantic proximity Read ↗

Interactions between the two surface proteins of rotavirus may alter the receptor-binding specificity of the virus.Semantic proximity Read ↗

Binding to sialic acids is not an essential step for the entry of animal rotaviruses to epithelial cells in culture.Semantic proximity Read ↗

Initial interaction of rotavirus strains with N-acetylneuraminic (sialic) acid residues on the cell surface correlates with VP4 genotype, not species of origin.Semantic proximity Read ↗

Reverse Genetics of Murine Rotavirus: A Comparative Analysis of the Wild-Type and Cell-Culture-Adapted Murine Rotavirus VP4 in Replication and Virulence in Neonatal MiceSemantic proximity Read ↗

Murine rotavirus genes encoding outer capsid proteins VP4 and VP7 are not major determinants of host range restriction and virulence.Semantic proximity Read ↗

Entry of rotaviruses is a multistep process.Semantic proximity Read ↗

Characterization of a monoclonal antibody directed to the surface of MA104 cells that blocks the infectivity of rotaviruses.Semantic proximity Read ↗

VLA-2 (α2β1) Integrin Promotes Rotavirus Entry into Cells but Is Not Necessary for Rotavirus AttachmentSemantic proximity Read ↗

A Lymphatic Mechanism of Rotavirus Extraintestinal Spread in the Neonatal MouseSemantic proximity Read ↗

A new cysteine in rotavirus VP4 participates in the formation of an alternate disulfide bond.Semantic proximity Read ↗

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