Rotavirus temperature-sensitive mutants are genetically stable and participate in reassortment during mixed infection of mice.

doi:10.1016/0042-6822(91)90587-2

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Article

Rotavirus temperature-sensitive mutants are genetically stable and participate in reassortment during mixed infection of mice.

Virology - 1 Jun 1991

Ramig R F, Gombold J L

Abstract excerpt

Mixed and single infections of 7-day-old suckling mice with SA11 temperature-sensitive (ts) mutants and RRV wild-type were examined to determine if selection against ts mutations occurred in the suckling mouse model. Single infections with ts mutants indicated that mutant replication was restrict...

Topics

Animals
Animals, Suckling
Mice
Mutation
RNA, Viral
Recombination, Genetic
Rotavirus
Rotavirus Infections
Selection, Genetic
Temperature
Virus Replication

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