Article
Rotavirus temperature-sensitive mutants are genetically stable and participate in reassortment during mixed infection of mice.
Virology - 1 Jun 1991
Ramig R F, Gombold J L
Abstract excerpt
Mixed and single infections of 7-day-old suckling mice with SA11 temperature-sensitive (ts) mutants and RRV wild-type were examined to determine if selection against ts mutations occurred in the suckling mouse model. Single infections with ts mutants indicated that mutant replication was restricted relative to wild-type and that disease was similarly reduced. Revertant (ts+) progeny did not appear to be selected...
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