Article
Defining the prognosis of early stage chronic lymphocytic leukaemia patients.
British journal of haematology - 1 Feb 2012
Pepper Chris, Majid Aneela, Lin Thet Thet, Hewamana Saman, Pratt Guy, Walewska Renata, Gesk Stefan, Siebert Reiner, Wagner Simon, Kennedy Ben, Miall Fiona, Davis Zadie A, Tracy Ian, Gardiner Anne C, Brennan Paul, Hills Robert K, Dyer Martin J S, Oscier David, Fegan Chris
Abstract excerpt
Approximately 70% of chronic lymphocytic leukaemia (CLL) patients present with early stage disease, therefore defining which patients will progress and require treatment is a major clinical challenge. Here, we present the largest study of prognostic markers ever carried out in Binet stage A patients (n = 1154) with a median follow-up of 8 years. We assessed the prognostic impact of lymphocyte doubling time (LDT),...
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