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Article

Poor vessel formation in embryos from knock-in mice expressing ALK5 with L45 loop mutation defective in Smad activation.

Laboratory investigation; a journal of technical methods and pathology - 1 Jul 2009

Itoh Fumiko, Itoh Susumu, Carvalho Rita L C, Adachi Tomomi, Ema Masatsugu, Goumans Marie-José, Larsson Jonas, Karlsson Stefan, Takahashi Satoru, Mummery Christine L, Dijke Peter Ten, Kato Mitsuyasu

Abstract excerpt

Transforming growth factor (TGF)-beta regulates vascular development through two type I receptors: activin receptor-like kinase (ALK) 1 and ALK5, each of which activates a different downstream Smad pathway. The endothelial cell (EC)-specific ALK1 increases EC proliferation and migration, whereas the ubiquitously expressed ALK5 inhibits both of these processes. As ALK1 requires the kinase activity of ALK5 for...

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Identifiers

PMID: 19398960
DOI: 10.1038/labinvest.2009.37

Genes

ALK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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