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Article

TGF-? receptor function in the endothelium

15 Dec 2004

Abstract excerpt

Genetic studies in mice and humans have revealed the pivotal role of transforming growth factor-beta (TGF-beta) signaling during angiogenesis. Mice deficient for various TGF-beta signaling components present an embryonic lethality due to vascular defects. In patients, mutations in the TGF-beta type I receptor ALK1 or in the accessory TGF-beta receptor endoglin are linked to an autosomal dominant disorder of...

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PMID: 15664386
DOI: 10.1016/j.cardiores.2004.10.036

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